PATH 7902 - Special Topics: Stem Cell Biology in Hematopoiesis and Other Systems

All cells of the immune system share a common origin with the remainder of the cells of the blood. Because these cells have a limited lifespan, a constant source of production must be maintained throughout adult life. Two distinct phases of blood development can be identified, functioning during either embryonic or adult life. Stem cells for other organs such as the nervous system function predominantly during embryogenesis and possess limited generative potential during adult life, although some organs (particularly the liver) retain significant regenerative abilities. How are these developmental systems related, and what are the essential differences? This course predominantly focuses on hematopoiesis as one of the best characterized mammalian developmental models, and also touches on stem cells for other organ systems. Topics include cell-cell interactions, soluble mediators of proliferation and differentiation, the importance of specific developmental environments in directing lineage commitment, and the major techniques that are utilized to study these questions.